Accordingly, provided are methods for the treatment of any indication associated with expression, such as inappropriate expression of plCSA, such as in cancer, arthritis, arthrosis, multiple sclerosis, pathological conditions caused by neural damage, conditions of the cartilage and scar tissue, such as in rheumatism, cartilage repair or wound healing, or in psoriasis; the methods comprising administering a therapeutically or prophylactically effective amount of a compound described herein to a subject in need thereof
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