However, our current study using adipocyte specific calpain 2 deficient mice and our earlier published study using leukocyte specific calpain 2 deficient mice 12 clearly demonstrated that 1 Ang II induced calpain 2 activation is associated with cytoskeletal structural protein and ECM destruction in the aorta and 2 calpain 2 derived from either adipocytes or leukocytes had no influence on Ang II induced AAA formation
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