As another non limiting example, synthetic immune response modifiers including, but not limited to, Tucaresol 4 2 formyl 3 hydroxy phenoxymethyl benzoic acid and its derivatives, and Isotucaresol and its derivatives can form Schiff base adducts with T cell surface amines and, in the presence of an antigen, provides co stimulatory signals to CD4 T cells, enhancing Th cell priming and CD8 cytotoxic T cell priming; leading to favorable therapeutic activity profiles in vivo 2 7 <a href=http://cialisshop.best>buy cialis online safely</a> Mol Diagn Ther 2012, 16 1 43 53