The facts that i the vast majority of disease genes 80 were concluded to be merely nonessential to the cell; ii the expression pattern of nonessential disease genes is decoupled from the overall expression pattern of all other genes, whereas essential genes have a tendency to be coupled to the rest of the cell and contribute most to the network entropy 132; and iii nonessential disease genes tend to occupy functionally peripheral and topologically neutral positions in the cellular network 126 confirm that diseases genes are activated in the context of metabolism rewiring under network dysregulation and suggest that their specific control would not impair the normal cell functioning
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