While estrogen is often thought of in terms of its key role in normal sexual development and reproduction, and while there is evidence of its immunomodulatory activities described above, the presence of estrogen receptors in a variety of other body tissues and organ systems including endometrium, breast, ovarian stromal and granulosa cells, hypothalamus, hippocampus, kidney, bone, heart, blood vessels, lungs, intestinal mucosa, prostate and endothelial cells suggests that estrogen plays an important role in a wide range of physiological processes including immune response 11, by a variety of mechanisms that include direct action on relevant cell types tissue
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