Although the burden of diabetes is well known, the natural history is well characterized, and there is good evidence for benefit from treating cases diagnosed in the context of usual clinical care, there are no randomized trials demonstrating the benefits of early diagnosis through screening of asymptomatic individuals 10.
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Establishing a causal connection between ingestion of a particular drug and the development of clinical depression is far from straightforward, notwithstanding epidemiological evidence linking some drugs with depression Rogers and Pies, 2008.