doxycycline side effects for dogs In compounds of Formula 1, each of R and R can be independently selected from hydrogen, halogen, C alkyl, C alkoxy, NO, substituted C alkyl, substituted C alkoxy, substituted C alkoxy, C heteroalkyl, substituted C heteroalkyl, and a chemotherapeutic moiety; each of R, R, and R can be selected from hydrogen, C alkyl, substituted C alkyl, and a chemotherapeutic moiety; R can be selected from COOH, OH, C alkoxy, C heteroalkyl, substituted C heteroalkyl, substituted C alkyl, and PH O OH; each R can be independently selected from hydrogen and hydroxyl