buy stromectol online usa By this crosslinking, a complex process is activated at the membrane level by an increase of membrane fluidity leading to IgE FcОµRI receptor clustering, degranulation of the cells and initiation of ionic fluxes into the basophilic cells which ultimately lead to the release of inflammatory mediators, such as histamine or sulfidoleukotrienes, as well as to the expression on, up regulation at or migration of glycoproteins to the basophil membrane