In a first aspect, the present invention provides a humanized antibody that binds a TGF beta comprising a variable heavy V H domain that comprises non human hypervariable region residues incorporated into a human V H domain, said variable domain comprising a framework region FR substitution in SEQ ID NO 6 at a position selected from the group consisting of 48, 49, 67, 69, 71, 73, and 78, utilizing the numbering system set forth in Kabat et al
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