The symptom onset — in the timeline of the development of the tumor — depends in many cases on the nature of the tumor as to it being benign or malignant , and in many cases is also related to the change in the nature of the neoplasm, from slow-growing, late-symptom-onset benign to faster-growing, early-symptom-onset malignant.
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To test this hypothesis, we trained and cross-validated score prediction and classification models Equations 6-7 using the procedure described in Model Evaluation.